Bare hos et mindretall er det funnet kjente sykdommer som kan medføre langvarig smerte, for eksempel artrose, revmatiske sykdommer eller nervelidelser.Betennelsesdempende: NSAIDs er smertestillende og betennelsesdempende legemidler som vil kunne redusere hevelsen på leddet og samtidig som de virker smertestillende.De sykdomsmodifiserende legemidl
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